Mutational consequences of hematopoietic stem cell transplantation in humans

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006824	Whole genome sequencing data (Illumina NovaSeq 6000) of clonal cultures derived from pediatric human bone marrow-derived hematopoietic stem and progenitor cells (in total 35 samples from 7 donors), bulk pediatric acute myeloid/lymphoid leukemia blasts (in total 2 samples from 1 patient) and bulk control mesenchymal stem cell cultures (4 samples from 4 patients) to study the mutation accumulation.	Illumina NovaSeq 6000	81

Publications	Citations
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients. de Kanter JK, Peci F, Bertrums E, Rosendahl Huber A, van Leeuwen A, van Roosmalen MJ, Manders F, Verheul M, Oka R, Brandsma AM, Bierings M, Belderbos M, van Boxtel R. Cell Stem Cell 28: 2021 1726-1739.e6	23
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells. Manders F, van Dinter J, van Boxtel R. iScience 25: 2022 105610	1